CoQ10 and Statins go hand in hand, while almost everyone can benefit from supplementing CoQ10 levels with a quality Ubiquinol CoQ10 supplement it is vital for those taking a Statin drug to supplement their CoQ10 levels. CoQ10 also functions as a powerful antioxidant to help fight free radicals that can damage cells and DNA. Super Ubiquinol CoQ10, 60 Softgel . 2003;18(1-4):113-24. And, what role does ubiquinol play in relation to statins? Filled with valuable tips and helpful advice. CoQ10 is produced in the body and sourced in a variety of foods. BJ: Ubiquinol is a liposoluble substance similar to a vitamin. Clin Chem. The key is that both cholesterol and coenzyme Q10 are produced in the body via the same pathway.  Take a look at the chart below.  You can see that acetoacetyl CoA gets changed into mevalonate.  This is done with the help of an enzyme called HMG-CoA reductase.  Mevalonate can then be used to make either cholesterol or coenzyme Q10.  This is called the mevalonate pathway (we've simplified the several steps in between for clarity).  Statins work by inhibiting the action of HMG-CoA reductase, so that the amount of mevalonate formed is decreased.  Without mevalonate, less cholesterol is formed, and this is exactly what you want to have happen for people whose cholesterol is too high.  But in so doing, we can't help but also decrease the amount coenzyme Q10 that the body makes. What is the Difference Between Coenzyme Q10 and Ubiquinol? So if you are on a statin drug, you can now understand why your doctor may have suggested that you take coenzyme Q10 or Ubiquinol alongside it.  In Canada, statin drug packages include a black box warning recommending that they be taken in conjunction with coenzyme Q10.Â. Ubiquinol is the ‘body ready’ antioxidant form, while ubiquinone is the inactive, oxidised form which your cells must first convert into ubiquinol for use. Some people who take statins report confusion or memory loss. 2001 Feb;47(2):256-65. Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Visit our Mental Health Hub to learn how to stay healthy, active, & keep your mind busy. Br. Anal Biochem. I bought a bottle of Ubiquinol yesterday at the Super Supplement store. Watts GF, Castellucci C, Rice-Evans C et al., Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. Ubiquinol is the active, antioxidant form of CoQ10. And if your cholesterol levels are high and you’re taking statins to manage this, you may also benefit from Ubiquinol, the most active and more readily absorbed form of CoQ10. Ubiquinol is the “spark plug” that helps fire energy production in your cells. 1992 Jun;295(2):230-4. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Taking CoQ10 and statins (such as lovastatin and simvastatin)? Quiz: Do You Take the Right Form of CoQ10? They work by inhibiting the body’s production of cholesterol, but in doing so, also deplete natural levels of CoQ10 (and therefore Ubiquinol) and may also deplete other essential vitamins and nutrients. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. J. Clin. Copyright © 2020 Kaneka North America LLC. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. All Rights Reserved. Never disregard or delay seeking medical advice because of something you have read on the internet. Cholesterol lowering statins are very effective but they also reduce the availability of Ubiquinol in your cells and in your heart. Cholesterol lowering statins are very effective but they also reduce the availability of Ubiquinol in your cells and in your heart. Aberg F, Appelkvist EL, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Passi S, Stancato A, Aleo E, Dmitrieva A, Littarru GP. However, too much cholesterol can cause health problems. Biofactors. This article is for general educational purposes only and is not intended to be used as or substituted for medical advice. Figure 1. If you have high cholesterol, your doctor may prescribe you a statin. Research also shows that when compared to conventional CoQ10, Ubiquinol is better able to replenish CoQ10 levels in statin users. Taking Statins medications will lower the natural level of Ubiquinol CoQ10 in our muscle tissue and most devastatingly our heart. J. Clin. Mol Aspects Med Suppl 1997;18: S137–144. However, one side effect of statins is their ability to lower CoQ10 levels.1-4 This means that by taking a statin, you’ll lower your cholesterol and may also lower your CoQ10 levels. ConsumerLab.com's answer explains. However, the lack of an effect may have been due to the small number of people studied as well as the short length of the study [74, 75]. CoQ10 Ubiquinol, supplement in the active antioxidant form, superior form of CoQ10 for cardiovascular and heart support and when taking statins. 3Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. J. Clin Pathol. 6Tang PH, Miles MV, DeGrauw A, Hershey A, Pesce A. HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma. With lowered CoQ10 levels due to statin use, LDL cholesterol becomes more susceptible to oxidation. Risa Schulman, Ph.D. took her lifelong love of science, people and the fulfillment of potential to create a multifaceted career in R&D, business, health and wellness, and empowering individuals. J. Clin. OK, Thanks for the information on dosage. Statins do not only limit the formation of cholesterol Continuous treatment with statins can also produce a deficiency in Ubiquinol. *These statements have not been evaluated by the Food and Drug Administration. Anal Biochem. Authors Siro Passi 1 , Andrea Stancato, Enrico Aleo, Anna Dmitrieva, Gian Paolo Littarru. Statins also interfere with the production of mevalonic acid, which is used to form CoQ10. Statins have been found to reduce the amount of naturally occurring coenzyme Q10 in the body. Mol Aspects Med Suppl 1997;18: S137–144. why your doctor may have suggested that you take coenzyme Q10 or Ubiquinol, https://pubmed.ncbi.nlm.nih.gov/14695926/, De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio.  Br. This article is for general educational purposes only and is not intended to be used as or substituted for medical advice. Knowduff.com explains the relationship between ubiquinol (a form of Coenzyme Q10) and cholesterol reduction, particularly LDL levels, which are the particles that are known to be the biggest contributors to the development of atherosclerosis. The information on this website is intended only for U.S. healthcare professionals. Watts GF, Castellucci C, Rice-Evans C et al., Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. 2001 Feb;47(2):256-65. 1996;42(3):333–337. Cholesterol is a naturally-occurring substance that’s found in every cell of your body and plays an important role in making hormones and vitamin D, and supporting digestion. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. Ubiquinol Supplementation with Statins. Statin Drugs and Ubiquinol Australia’s use of cholesterol-lowering drugs is the highest in the developed world and has become accepted as an important tool to help reduce the risk of heart disease 1. Several studies have shown that Ubiquinol effectively restores the CoQ10 that statins can deplete over time. Because coenzyme Q10 plays a role in muscle cell energy production, some researchers have proposed that taking a coenzyme Q10 supplement might reduce the risk of muscle-related side effects. for further information) in the blood, particularly in people who have been on statins at high doses or for a long time.  Even small decreases in CoQ10 can disrupt the body's ability to produce energy and cause other compromises in function.  For example, in some people taking statins, the lowering of CoQ10 is associated with a weakening of the heart muscle, and overall muscular pain (cardiomyalgia). Perhaps more than you think. Ubiquinol Depleting Statins Statin drugs work by inhibiting your body’s production of cholesterol but they also deplete your natural Ubiquinol and other essential nutrients and vitamins. Br. 1Passi S, Stancato A, Aleo E, Dmitrieva A, Littarru GP. Since Ubiquinol is required for 95% of your body’s cellular production, maintaining the proper levels of this nutrient is essential for your organs to function optimally 6,7,8 . Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA Biofactors. This is because our bodies use the same compound to make both cholesterol and CoQ10. Cells use it to generate energy. It provides for each cell the energy necessary for the human body to function properly. Mol Aspects Med Suppl  1997;18: S137–144. Ubiquinol supplementation led to a 1.5-fold increase in the amount of CoQ10 in the blood. 2 De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. In addition, Ubiquinol is usually the first line of antioxidant defense that neutralizes the oxidation of low density lipoprotein (LDL) cholesterol, which otherwise can lead to the development of atherosclerosis.  But in people with lowered CoQ10 levels due to statin use, LDL cholesterol was more susceptible to oxidation.5  Â. This has been shown to significantly decrease CoQ10 levels in the blood and muscle tissues ( 10 ). Always seek the advice of your physician or qualified health care provider with any questions about your health or a medical condition. Stuck at home? Visit our Mental Health Hub to learn how to stay healthy, active, & keep your mind busy. 1996;42(3):333–337. As the body’s strongest fat-soluble antioxidant, Ubiquinol can help defend against the oxidation of LDL cholesterol by inactivating free radicals. these drugs inhibit the body's production of coenzyme Q10. *These statements have not been evaluated by the Food and Drug Administration. 1992 Jun;295(2):230-4. Although ubiquinone reduces muscle pain caused by statins, one study found that ubiquinol (600 mg/day) had no effect .Statins can also impair the function of mitochondria by reducing CoQ10 levels. Copyright © 2020 Kaneka North America LLC. J. Clin Pathol. Ubiquinol is the only form of CoQ10 that exists as an antioxidant. Tang PH, Miles MV, DeGrauw A, Hershey A, Pesce A. HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma. Sometimes Ubiquinol supplements are labelled “CoQ10 Ubiquinol” to take advantage of the more familiar CoQ10 name. On Sale Now: High Quality Ubiquinol CoQ10.  Always seek the advice of your physician or qualified health care provider with any questions about your health or a medical condition.  Never disregard or delay seeking medical advice because of something you have read on the internet. Clin Chem. For example, in some people taking statins, the lowering of CoQ10 is associated with a weakening of the heart muscle, and overall muscular pain (cardiomyalgia). Although statins are well tolerated by most people, they can cause muscle and joint aches. Information on this site is for informational purposes only and is not a substitute for medical advice. Ubiquinol (600 mg/day) did not improve mitochondrial function compared to placebo in a 4-week study of 21 people taking statins. Biofactors. Copyright © 2020 Kaneka North America LLC. Pharmacol. Lowering levels of CoQ10 in our bodies is a sure way to increase cellular damage, increase cellular toxicity and greatly increase our risk of disease. Acetoacetyl-CoA is changed into mevalonate with the help of the enzyme HMG-CoA reductase.  From there, mevalonate can be used to synthesize both cholesterol and coenzyme Q10.  Statins work by inhibiting the action of HMG-CoA reductase, thereby decreasing the amount of mevalonate available to make either cholesterol or coenzyme Q10.Â. Risa Schulman, Ph.D. took her lifelong love of science, people and the fulfillment of potential to create a multifaceted career in R&D, business, health and wellness, and empowering individuals. All Rights Reserved. MYTH 1 Statins cause memory loss. Luckily, by taking a Ubiquinol CoQ10 dietary supplement, you can replenish depleted levels of this important nutrient. Mitochondria are the energy factories of the human cells and coenzyme Q10 (CoQ10) is an essential component for healthy cell function.CoQ10 is required to extract energy from fats and sugars.However, the production of CoQ10 in our body declines as we age and we need to supplement the daily need. Stuck at home? Benefits of … This product is not intended to diagnose, treat, cure or prevent any disease. Copyright © 2020 Kaneka North America LLC. Look for the word “Ubiquinol” or “Reduced CoQ10” on the label or the Supplement Facts panel to ensure you are getting the more absorbable form of CoQ10. J. Clin Pathol. All Rights Reserved. When you use a statin to block the production of too much cholesterol, it also inhibits your body from producing normal levels of CoQ10. My primary doc suggested I take Ubiquinol instead of Coq10 when I saw her last month for check up and told her I went off statins and started myself on Coq10. It acts as an antioxidant, which is a molecule that inhibits the oxidation of other molecules. CoQ10 (Coenzyme Q10) is one of the most popular heart health supplements used by those taking statin medications to lower their cholesterol. The natural level of Ubiquinol in your heart fat-soluble antioxidant, Ubiquinol goes a step further substance to! Blood and muscle tissues ( 10 ) S, Stancato a, Littarru GP detection of Ubiquinol your... Rice-Evans C et al., plasma coenzyme Q ( ubiquinone ) concentrations in treated! Compound to make both cholesterol and CoQ10 help defend against the oxidation other. Antioxidant form of CoQ10 for cardiovascular and heart support and when taking statins medications will the... The Ubiquinol form is best their cholesterol up tourists from the WRONG locations and put in. Ubiquinol” to take advantage of the more familiar CoQ10 name health supplements used by those taking statin to. 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